- substrate = a'-enolizable a-halo-ketone
mechanism:
remarks:
The reaction is both regio- and stereoselective.
There are two major variations of the Favorskii rearrangement: the homo-Favorskii's when b-halo-ketones are treated with base in the presence of a nucleophile, going through the corresponding cyclobutanone, and the quasi-Favorskii's when the a-halo-ketone does not have any enolizable hydrogen.
example:
references:
Synth. Commun. 2006, 36, 259. Eur. J. Org. Chem. 2005, 4687. Curr. Org. Chem. 2005, 9, 1713. Tetrahedron 1986, 42, 1621. Tetrahedron Lett. 1981, 22, 1733. J. Am. Chem. Soc. 1961, 83, 3980. Organic Reactions 1960, 11, 261.
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