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   REFORMATSKY reaction


mechanism:

null


remarks:

  • The use of zinc allows the enolate generation without using any Bronsted base which could condense the ketone (aldehyde) on itself.
  • See also: the Claisen condensation, the Baylis-Hillman reaction and the Blaise reaction


references:

Org. Lett. 2003, 5, 451.
J. Org. Chem. 1993, 58, 6360.
J. Org. Chem. 1989, 54, 681.
Synthesis 1989, 571.
J. Org. Chem. 1978, 43, 1750.
Org. React. 1975, 22, 423.
Org. React. 1942, 1, 1.